Methylamine → HCID 67501354, compound

HRID 1631327Notes

Reaction equation

HRID 1631327 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C@H:8]2[CH2:12][C@@H:11]([OH:13])[CH2:10][N:9]2[C:14]2[CH:19]=[CH:18][N:17]3[N:20]=[CH:21][C:22]([C:23]([OH:25])=O)=[C:16]3[N:15]=2)[CH:5]=[CH:6][CH:7]=1.[CH3:26][NH2:27]>>[F:1][C:2]1[CH:3]=[C:4]([C@H:8]2[CH2:12][C@@H:11]([OH:13])[CH2:10][N:9]2[C:14]2[CH:19]=[CH:18][N:17]3[N:20]=[CH:21][C:22]([C:23]([NH:27][CH3:26])=[O:25])=[C:16]3[N:15]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 66847779HCID 66847779, compound

Product 1

HCID 67501354HCID 67501354, compoundYield 45%

Procedure

Prepared by the method described in Example 1 using 5-((2R,4R)-2-(3-fluorophenyl)-4-hydroxypyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid and methylamine to provide the final product as a white solid (9.4 mg, 45% yield). MS (apci) m/z=356.1 (M+H).

Workup

  1. customPrepared by the method

Sources & evidence

ORD record
ord-43b98f7658af4faf93f3c65d1d4c6349
Source dataset
uspto-grants-2014_07
Patent number
US08791123B2

Reaction notes

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