Hydrochloric Acid → HCID 67501201, compound

HRID 1631338Notes

Reaction equation

HRID 1631338 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C@H:9]1[CH2:13][CH2:12][CH2:11][N:10]1[C:14]1[CH:19]=[CH:18][N:17]2[N:20]=[CH:21][C:22]([C:23]([NH:25][C:26]([CH3:37])([CH3:36])[CH2:27][NH:28]C(=O)OC(C)(C)C)=[O:24])=[C:16]2[N:15]=1.[ClH:38].O1CCOCC1>C(Cl)Cl>[ClH:38].[NH2:28][CH2:27][C:26]([NH:25][C:23]([C:22]1[CH:21]=[N:20][N:17]2[CH:18]=[CH:19][C:14]([N:10]3[CH2:11][CH2:12][CH2:13][C@@H:9]3[C:3]3[CH:4]=[C:5]([F:8])[CH:6]=[CH:7][C:2]=3[F:1])=[N:15][C:16]=12)=[O:24])([CH3:37])[CH3:36]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 66848131HCID 66848131, compound

Product 1

HCID 67501201HCID 67501201, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(R)-tert-butyl 2-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamido)-2-methylpropylcarbamate (109 mg, 0.212 mmol) was dissolved in DCM (1.0 mL) and 4N HCl in dioxane (0.530 mL, 2.12 mmol) was added. The mixture was stirred at ambient temperature for 4 hours and was concentrated afford the title compound (105 mg). MS (apci) m/z=415.2 (M+H).

Workup

  1. concentrationwas concentrated

Sources & evidence

ORD record
ord-eccb8f64700b41728377c7de1db46c82
Source dataset
uspto-grants-2014_07
Patent number
US08791123B2

Reaction notes

Loading…