4-Aminotetrahydropyran → HCID 67501419, compound

HRID 1631351Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([C@H:8]2[CH2:12][CH2:11][CH2:10][N:9]2[C:13]2[CH:18]=[CH:17][N:16]3[N:19]=[CH:20][C:21]([C:22]([OH:24])=O)=[C:15]3[N:14]=2)[CH:5]=[N:6][CH:7]=1.[O:25]1[CH2:30][CH2:29][CH:28]([NH2:31])[CH2:27][CH2:26]1>>[F:1][C:2]1[CH:3]=[C:4]([C@H:8]2[CH2:12][CH2:11][CH2:10][N:9]2[C:13]2[CH:18]=[CH:17][N:16]3[N:19]=[CH:20][C:21]([C:22]([NH:31][CH:28]4[CH2:29][CH2:30][O:25][CH2:26][CH2:27]4)=[O:24])=[C:15]3[N:14]=2)[CH:5]=[N:6][CH:7]=1

Participants

Reactant 2

HCID 4192234-Aminotetrahydropyran

HCID 66847898HCID 66847898, compound

Product 1

HCID 67501419HCID 67501419, compoundYield 90%

Procedure

Prepared by the method as described in Example 1 using (R)-5-(2-(5-fluoropyridin-3-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (Preparation I) and tetrahydro-2H-pyran-4-amine to yield the title compound as a white solid (34 mg, 90% yield). MS (apci) m/z=411.1 (M+H).

Workup

customPrepared by the method

Sources & evidence

ORD record: ord-8e1330d4881d46f2a4758463230bd7c3
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08791123B2

Reaction notes

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