Ammonium Chloride → HCID 66886318, compound

HRID 1631368Notes

Reaction equation

HRID 1631368 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:25][CH2:26][CH2:27][O:28][CH3:29])=[C:6]([C@H:8]2[CH2:12][CH2:11][CH2:10][N:9]2[C:13]2[CH:18]=[CH:17][N:16]3[N:19]=[CH:20][C:21]([C:22](O)=[O:23])=[C:15]3[N:14]=2)[CH:7]=1.[Cl-].[NH4+:31]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:25][CH2:26][CH2:27][O:28][CH3:29])=[C:6]([C@H:8]2[CH2:12][CH2:11][CH2:10][N:9]2[C:13]2[CH:18]=[CH:17][N:16]3[N:19]=[CH:20][C:21]([C:22]([NH2:31])=[O:23])=[C:15]3[N:14]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 25517Ammonium ChlorideHCID 66853957HCID 66853957, compound

Product 1

HCID 66886318HCID 66886318, compoundYield 55%

Procedure

Prepared by the method described in Example 76, Step F using (R)-5-(2-(5-fluoro-2-(2-methoxyethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid and ammonium chloride to yield the title compound as a white solid (32.6 mg, 55% yield). MS (apci) m/z=400.1 (M+H).

Workup

  1. customPrepared by the method

Sources & evidence

ORD record
ord-068d12f294044d9fad1af30c62c443cc
Source dataset
uspto-grants-2014_07
Patent number
US08791123B2

Reaction notes

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