Hydrochloric Acid → 1-(Trifluoromethyl)cyclopropanamine hydrochloride

Participants

Reaction Steps

A solution of tert-butyl 1-(trifluoromethyl)cyclopropylcarbamate (0.3 g, 1.3 mmol) in HCl (4 N dioxane, 6.7 mL, 27 mmol) was stirred at ambient temperature overnight. The reaction was then concentrated to yield the crude product as white solid, which was used directly in the next step assuming quantitative yield.

Provenance & Evidence