(S)-1,1,1-trifluoropropan-2-amine → HCID 67500680, compound

HRID 1631407Notes

Reaction equation

HRID 1631407 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C@@H:8]2[N:12]([C:13]3[CH:18]=[CH:17][N:16]4[N:19]=[CH:20][C:21]([C:22](O)=[O:23])=[C:15]4[N:14]=3)[C@@:11]([CH2:26][OH:27])([CH3:25])[CH2:10][CH2:9]2)[CH:5]=[N:6][CH:7]=1.[F:28][C:29]([F:34])([F:33])[C@@H:30]([NH2:32])[CH3:31]>>[F:1][C:2]1[CH:3]=[C:4]([C@@H:8]2[N:12]([C:13]3[CH:18]=[CH:17][N:16]4[N:19]=[CH:20][C:21]([C:22]([NH:32][C@@H:30]([CH3:31])[C:29]([F:34])([F:33])[F:28])=[O:23])=[C:15]4[N:14]=3)[C@@:11]([CH2:26][OH:27])([CH3:25])[CH2:10][CH2:9]2)[CH:5]=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 10964447(S)-1,1,1-trifluoropropan-2-amineHCID 66847957HCID 66847957, compound

Product 1

HCID 67500680HCID 67500680, compound

Procedure

Prepared according to the method of Example 212, Step F, using 54(2S,5R)-5-(5-fluoropyridin-3-yl)-2-(hydroxymethyl)-2-methylpyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (Example 219, Step F) and (S)-1,1,1-trifluoropropan-2-amine. The title compound was obtained as a white solid (5.4 mg, 31% yield). MS (apci) m/z=467.1 (M+H).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d8c88a21c185406688c23a53308a5de1
Source dataset
uspto-grants-2014_07
Patent number
US08791123B2

Reaction notes

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