Hydrochloric Acid → HCID 86664586, compound

HRID 1631411Notes

Reaction equation

[Cl:1][C:2]1[C:7]([C@H:8]2[CH2:12][CH2:11][CH2:10][N:9]2[C:13]2[CH:18]=[CH:17][N:16]3[N:19]=[CH:20][C:21]([C:22]([NH:24][CH2:25][CH2:26][CH2:27][NH:28]C(=O)OC(C)(C)C)=[O:23])=[C:15]3[N:14]=2)=[CH:6][C:5]([F:36])=[CH:4][N:3]=1.Cl>>[NH2:28][CH2:27][CH2:26][CH2:25][NH:24][C:22]([C:21]1[CH:20]=[N:19][N:16]2[CH:17]=[CH:18][C:13]([N:9]3[CH2:10][CH2:11][CH2:12][C@@H:8]3[C:7]3[C:2]([Cl:1])=[N:3][CH:4]=[C:5]([F:36])[CH:6]=3)=[N:14][C:15]=12)=[O:23]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 86664587HCID 86664587, compound

Product 1

HCID 86664586HCID 86664586, compound

Procedure

A mixture of (R)-tert-butyl 3-(5-(2-(2-chloro-5-fluoropyridin-3-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamido)propylcarbamate (Example 222, 6 mg, 0.012 mmol) and HCl (4 N dioxane, 145 μL, 0.58 mmol) was stirred at ambient temperature for 2 hours and concentrated to yield the product as white solid. LCMS (apci pos) m/z=418.1 (M+H).

Workup

concentrationconcentrated

Sources & evidence

ORD record: ord-86b87a8c6b9346718be548278ade50c8
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08791123B2

Reaction notes

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