Hydrochloric Acid → HCID 86664588, compound

HRID 1631412Notes

Reaction equation

HRID 1631412 reaction equation
C([O:5][CH2:6][CH2:7][O:8][NH:9][C:10]([C:12]1[CH:13]=[N:14][N:15]2[CH:20]=[CH:19][C:18]([N:21]3[CH2:25][CH2:24][CH2:23][C@@H:22]3[C:26]3[C:27]([Cl:33])=[N:28][CH:29]=[C:30]([F:32])[CH:31]=3)=[N:17][C:16]=12)=[O:11])(C)(C)C.Cl>CO>[Cl:33][C:27]1[C:26]([C@H:22]2[CH2:23][CH2:24][CH2:25][N:21]2[C:18]2[CH:19]=[CH:20][N:15]3[N:14]=[CH:13][C:12]([C:10]([NH:9][O:8][CH2:7][CH2:6][OH:5])=[O:11])=[C:16]3[N:17]=2)=[CH:31][C:30]([F:32])=[CH:29][N:28]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86664589HCID 86664589, compound

Product 1

HCID 86664588HCID 86664588, compound

Reagents, catalysts & solvents 1

HCID 887MethanolCatalyst

Procedure

(R)—N-(2-tert-butoxyethoxy)-5-(2-(2-chloro-5-fluoropyridin-3-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide (Example 224, 57 mg, 0.120 mmol) was treated with HCl (4 N dioxane, 1.49 mL, 5.98 mmol), followed by two drops of MeOH to make a clear colorless solution. After stirring 30 minutes at ambient temperature, the reaction was concentrated and dried to yield the title product as white solid, assuming quantitative yield. LCMS (apci) m/z=421.0 (M+H)

Workup

  1. concentrationthe reaction was concentrated
  2. customdried

Sources & evidence

ORD record
ord-a93bf7f60a744e25a000180ccf028759
Source dataset
uspto-grants-2014_07
Patent number
US08791123B2

Reaction notes

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