Tert-Butylamine → HCID 67501347, compound

HRID 1631413Notes

Reaction equation

HRID 1631413 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C@H:10]2[CH2:14][CH2:13][CH2:12][N:11]2[C:15]2[CH:20]=[CH:19][N:18]3[N:21]=[CH:22][C:23]([C:24]([OH:26])=O)=[C:17]3[N:16]=2)[C:5](=[O:9])[N:6]([CH3:8])[CH:7]=1.[CH3:27][C:28]([NH2:31])([CH3:30])[CH3:29]>>[C:28]([NH:31][C:24]([C:23]1[CH:22]=[N:21][N:18]2[CH:19]=[CH:20][C:15]([N:11]3[CH2:12][CH2:13][CH2:14][C@@H:10]3[C:4]3[C:5](=[O:9])[N:6]([CH3:8])[CH:7]=[C:2]([F:1])[CH:3]=3)=[N:16][C:17]=12)=[O:26])([CH3:30])([CH3:29])[CH3:27]

Participants

3

Reactant 2

HCID 6385Tert-ButylamineHCID 66853045HCID 66853045, compound

Product 1

HCID 67501347HCID 67501347, compoundYield 75%

Procedure

Prepared by the method described in Example 140, using (R)-5-(2-(5-fluoro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (Preparation R) and 2-methylpropan-2-amine. The residue was purified by silica column chromatography, eluting with 3% MeOH/DCM to yield the title compound (26 mg, 75% yield). MS (apci) m/z=413.1 (M+H).

Workup

  1. customPrepared by the method
  2. customThe residue was purified by silica column chromatography
  3. washeluting with 3% MeOH/DCM

Sources & evidence

ORD record
ord-422c970ad2d14d72a34c4f6996c53b1f
Source dataset
uspto-grants-2014_07
Patent number
US08791123B2

Reaction notes

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