1-(Bromomethyl)-4-(trifluoromethyl)benzene → HCID 11566711, compound

HRID 1631476Notes

Reaction equation

HRID 1631476 reaction equation
C[O:2][C:3](=[O:27])[CH2:4][C:5]1[C:13]2[C:8](=[N:9][CH:10]=[CH:11][CH:12]=2)[N:7]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[C:6]=1[CH2:25][CH3:26].COC(=O)CC1C2C(=NC=CC=2)NC=1CC.CCN(P1(N(C)CCCN1C)=NC(C)(C)C)CC.FC(F)(F)C1C=CC(CBr)=CC=1>CN(C=O)C.O>[CH2:25]([C:6]1[N:7]([CH2:14][C:15]2[CH:16]=[CH:17][C:18]([C:21]([F:24])([F:22])[F:23])=[CH:19][CH:20]=2)[C:8]2=[N:9][CH:10]=[CH:11][CH:12]=[C:13]2[C:5]=1[CH2:4][C:3]([OH:27])=[O:2])[CH3:26]

Participants

7

Reactant 4

HCID 1230621-(Bromomethyl)-4-(trifluoromethyl)benzeneHCID 35138512-((1,1-Dimethylethyl)imino)-N,N-diethylhexahydro-1,3-dimethyl-2lambda5-1,3,2-diazaphosphorin-2-amineHCID 67219240HCID 67219240, compoundHCID 67219373HCID 67219373, compound

Product 1

HCID 11566711HCID 11566711, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

[2-Ethyl-1-(4-trifluoromethyl-benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-acetic acid methyl ester: To an ice-cooled stirring solution of (2-ethyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-acetic acid methyl ester (80 mg, 0.37 mmol) in DMF (1 ml) is added BEMP (171 μl, 0.59 mmol). The solution is stirred at room temperature for 40 minutes and then re-cooled. 4-(Trifluoromethyl)benzyl bromide (91 μl, 0.59 mmol) is added and stirring continues while the reaction mixture gradually warmed up to room temperature overnight. The resulting mixture is poured into water (30 ml) and extracted with 1:1 EtOAc/ether. The organic layer is washed with brine, dried (Na2SO4) and concentrated in vacuo. The residue is loaded on a pre-packed Isolute™ silica column and eluted with DCM to yield the titled compound as a pale yellow oil. (MH+ 377)

Workup

  1. temperaturere-cooled
  2. stirringstirring
  3. temperaturegradually warmed up to room temperature overnight
  4. extractionextracted with 1:1 EtOAc/ether
  5. washThe organic layer is washed with brine
  6. dry with materialdried (Na2SO4)
  7. concentrationconcentrated in vacuo
  8. washeluted with DCM

Sources & evidence

ORD record
ord-413ad19d03d243f593af7130a776573c
Source dataset
uspto-grants-2014_07
Patent number
US08791256B2

Reaction notes

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