Sodium Hydroxide → HCID 140606267, compound

HRID 1631540Notes

Reaction equation

HRID 1631540 reaction equation
[OH-].[Na+].S(O)(O)(=O)=O.[CH3:8][S:9][C:10](=[NH:12])[NH2:11].[NH2:13][C:14]1[C:15]([C:24](OC(C)=CC(=O)NC(C)(C)C)=[O:25])=[N:16][C:17]2[C:22]([N:23]=1)=[CH:21][CH:20]=[CH:19][CH:18]=2>C1COCC1>[NH2:13][C:14]1[C:15]([C:24]([NH:12][C:10]([S:9][CH3:8])=[NH:11])=[O:25])=[N:16][C:17]2[C:22]([N:23]=1)=[CH:21][CH:20]=[CH:19][CH:18]=2

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 752702-Methyl-2-thiopseudourea sulfateHCID 86682674HCID 86682674, compound

Product 1

HCID 140606267HCID 140606267, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To NaOH (1 mol/l in water; 45.7 ml; 45.7 mmol) is added S-methylisothiourea sulphate (10.6 g; 38.1 mmol). The mixture is stirred until complete solution is achieved. The resulting solution is added to a suspension of 1-(tert-butylcarbamoyl)prop-1-en-2-yl 3-aminoquinoxaline-2-carboxylate (example 4) (5.00 g; 15.2 mmol) in THF (80 ml). The mixture is stirred at r.t. for 3 h, then volatiles are evaporated. Ice-water (100 ml) is added. The precipitate formed is filtered off with suction, washed with water and then dried at 50° C. (C11H11N5OS).

Workup

  1. stirringThe mixture is stirred at r.t. for 3 h
  2. customvolatiles are evaporated
  3. additionIce-water (100 ml) is added
  4. customThe precipitate formed
  5. filtrationis filtered off with suction
  6. washwashed with water
  7. customdried at 50° C. (C11H11N5OS)

Sources & evidence

ORD record
ord-c796d6c5aeb44507ad5fe3d969b6f865
Source dataset
uspto-grants-2014_07
Patent number
US08791260B2

Reaction notes

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