4,5-dihydro-1H-imidazol-2-ylamine tosylate → 3,5-diamino-6-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)pyrazine-2-carboxamide

HRID 1631542노트

반응식

HRID 1631542 반응식
S(C1C=CC(C)=CC=1)(O)(=O)=O.[NH:12]1[CH2:16][CH2:15][N:14]=[C:13]1[NH2:17].[Na].[NH2:19][C:20]1[C:21]([C:28](OC(C)=CC(=O)NC(C)(C)C)=[O:29])=[N:22][C:23]([Cl:27])=[C:24]([NH2:26])[N:25]=1>CC(O)C>[NH2:19][C:20]1[C:21]([C:28]([NH:17][C:13]2[NH:14][CH2:15][CH2:16][N:12]=2)=[O:29])=[N:22][C:23]([Cl:27])=[C:24]([NH2:26])[N:25]=1

참가 물질

5

반응물 3

HCID 2865314,5-dihydro-1H-imidazol-2-ylamine tosylateHCID 5360545SodiumHCID 540167941-(Tert-butylcarbamoyl)prop-1-en-2-yl 3,5-diamino-6-chloropyrazine-2-carboxylate

생성물 1

HCID 203583433,5-diamino-6-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)pyrazine-2-carboxamide

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

A mixture of 4,5-dihydro-1H-imidazol-2-ylamine tosylate (1.69 g; 6.57 mmol) and sodium (119 mg; 5.19 mmol) in 2-propanol (20 ml) is refluxed for 30 min. 1-(tert-Butylcarbamoyl)prop-1-en-2-yl 3,5-diamino-6-chloropyrazine-2-carboxylate (example 2) (0.900 g; 2.75 mmol) is added and the mixture is refluxed for further 60 min. The precipitate formed is filtered off with suction, suspended in water, filtered off again and dried at 50° C. to yield the title compound (C8H10ClN7O).

후처리

  1. temperatureis refluxed for 30 min
  2. temperaturethe mixture is refluxed for further 60 min
  3. customThe precipitate formed
  4. filtrationis filtered off with suction
  5. filtrationfiltered off again
  6. customdried at 50° C.

출처 및 근거

ORD 기록
ord-9d84f6855c8c4888a9fb35bf6340170b
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08791260B2

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