2,4,5-Trifluoroaniline → HCID 136352201, compound

HRID 1631607Notes

Reaction equation

HRID 1631607 reaction equation
[N:1]1([C:7]2[N:8]=[C:9]([CH2:14][C:15]([O-:17])=O)[NH:10][C:11](=[O:13])[CH:12]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Na+].[F:19][C:20]1[CH:26]=[C:25]([F:27])[C:24]([F:28])=[CH:23][C:21]=1[NH2:22]>>[N:1]1([C:7]2[N:8]=[C:9]([CH2:14][C:15]([NH:22][C:21]3[CH:23]=[C:24]([F:28])[C:25]([F:27])=[CH:26][C:20]=3[F:19])=[O:17])[NH:10][C:11](=[O:13])[CH:12]=2)[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 949532,4,5-TrifluoroanilineHCID 136041844Sodium (4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetate

Product 1

HCID 136352201HCID 136352201, compoundYield 62.7%

Procedure

The product is prepared according to the procedure described in Example 5, using 260 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 294 mg of 2,4,5-trifluoroaniline in place of the 2,4-difluoroaniline. 230 mg of 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-(2,4,5-trifluorophenyl)acetamide are obtained in the form of a white solid, the characteristics of which are the following:

Workup

  1. customThe product is prepared

Sources & evidence

ORD record
ord-554f9badc93d442788ab3e8cecd70927
Source dataset
uspto-grants-2014_07
Patent number
US08791255B2

Reaction notes

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