反应详情

The title compound was prepared in a manner similar to EXAMPLE 1 using 2-chloro-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine (PREPARATION x2, 50 mg, 0.221 mmol), 1H-benzo[d]imidazol-4-ylboronic acid (71.5 mg, 0.441 mmol) and PdCl2(dppf) (12.91 mg, 0.018 mmol) in dioxane (2 mL) and aqueous saturated NaHCO3 (0.4 mL). 1H NMR (400 MHz, DMSO-d6) δ 3.03 (dd, J=11.87, 8.59 Hz, 1H), 3.33-3.75 (m, 5H), 3.98 (m, 2H), 4.74-4.84 (m, 1H), 6.49-7.07 (br s, 1H), 7.54 (t, J=7.83 Hz, 1H), 7.79-7.91 (m, 2H), 8.25-8.33 (m, 1H), 8.98 (s, 1H), 12.18-12.29 (m, 1H). ESI-MS m/z [M+H]+ calc'd for C16H16N6O, 309.14. found 309.3.