4-Aminopyridine → HCID 787482, compound

HRID 1631820Notes

Reaction equation

HRID 1631820 reaction equation
[C:1]([OH:11])(=O)/[CH:2]=[CH:3]/[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[NH2:12][C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1.C1CCC(N=C=NC2CCCCC2)CC1>>[N:16]1[CH:17]=[CH:18][C:13]([NH:12][C:1](=[O:11])[CH:2]=[CH:3][C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=2)=[CH:14][CH:15]=1

Participants

4

Reactant 3

HCID 17274-AminopyridineHCID 10868DicyclohexylcarbodiimideHCID 444539Cinnamic Acid

Product 1

HCID 787482HCID 787482, compoundYield 68%

Procedure

Reaction of trans-cinnamic acid (0.74 g, 5.00 mmol) with 4-aminopyridine (0.47 g, 5.00 mmol) was conducted according to the general amide coupling procedure using DCC to obtain the product as a white solid (0.76 g, 68%). EIMS m/z: 225 ([M]+), 223 ([M]−).

Sources & evidence

ORD record
ord-5384f2656d1744a0b36f21a72c5c5c17
Source dataset
uspto-grants-2014_07
Patent number
US08791275B2

Reaction notes

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