4-Aminopyridine → HCID 5889695, compound

HRID 1631821Notes

Reaction equation

HRID 1631821 reaction equation
[CH3:1][O:2][C:3]1[CH:13]=[CH:12][C:6]([CH:7]=[CH:8][C:9]([OH:11])=O)=[CH:5][CH:4]=1.[NH2:14][C:15]1[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=1.C1CCC(N=C=NC2CCCCC2)CC1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6](/[CH:7]=[CH:8]/[C:9]([NH:14][C:15]2[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=2)=[O:11])=[CH:12][CH:13]=1

Participants

4

Reactant 3

HCID 17274-AminopyridineHCID 10868DicyclohexylcarbodiimideHCID 132454-Methoxy cinnamic acid

Product 1

HCID 5889695HCID 5889695, compoundYield 14.2%

Procedure

Reaction of 4-methoxycinnamic acid (0.89 g, 5.00 mmol) with 4-aminopyridine (0.47 g, 5.00 mmol) was conducted according to the general amide coupling procedure using DCC to obtain the product as a white solid (0.18 g, 14%). EIMS m/z: 255 ([M]+).

Sources & evidence

ORD record
ord-7620068a4b994721a86ad0f0e142b2fb
Source dataset
uspto-grants-2014_07
Patent number
US08791275B2

Reaction notes

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