Water → (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methoxypropyl)-phenol hydrochloride

HRID 1631843Notes

Reaction equation

[CH3:1][N:2]([CH3:17])[CH2:3][C@H:4]([O:15][CH3:16])[C@@H:5]([C:8]1[CH:9]=[C:10]([OH:14])[CH:11]=[CH:12][CH:13]=1)[CH2:6][CH3:7].O.C[Si](C)(C)[Cl:21]>CC(=O)CC>[ClH:21].[CH3:17][N:2]([CH3:1])[CH2:3][C@H:4]([O:15][CH3:16])[C@@H:5]([C:8]1[CH:9]=[C:10]([OH:14])[CH:11]=[CH:12][CH:13]=1)[CH2:6][CH3:7]

Participants

Conditions

Temperature: 22.5 °C

Procedure

Part of the oil obtained in Example 6 is dissolved in 2-butanone (40 mL) at the temperature of 20-25° C. The following are added: purified water (0.3 mL, 0.0167 moles), trimethylchlorosilane (1.2 g). The hydrochloride product precipitates and the suspension is maintained under stirring for 4 hours at the temperature of 20-25° C. Finally, the solid is filtered, and this is dried under vacuum at 30-40° C.

Workup

additionThe following are added
customThe hydrochloride product precipitates
temperaturethe suspension is maintained
filtrationFinally, the solid is filtered
customthis is dried under vacuum at 30-40° C.

Sources & evidence

ORD record: ord-986abd2bc89640a481ddf60562d29772
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08791287B2

Reaction notes

Loading…