HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1631843Generated: November 3, 2026
Water → (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methoxypropyl)-phenol hydrochloride
https://huagongshe.com/reaction/1631843
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methoxypropyl)-phenol | HCID 86690044 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methoxypropyl)-phenol hydrochloride | HCID 86690045 | — |
Reaction Steps
Part of the oil obtained in Example 6 is dissolved in 2-butanone (40 mL) at the temperature of 20-25° C. The following are added: purified water (0.3 mL, 0.0167 moles), trimethylchlorosilane (1.2 g). The hydrochloride product precipitates and the suspension is maintained under stirring for 4 hours at the temperature of 20-25° C. Finally, the solid is filtered, and this is dried under vacuum at 30-40° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08791287B2 |
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| Source dataset | uspto-grants-2014_07 |
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| ORD ID | ord-986abd2bc89640a481ddf60562d29772 |
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| Source note | uspto-grants-2014_07 |
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