Potassium Carbonate → HCID 59609085, compound

HRID 1631861Notes

Reaction equation

HRID 1631861 reaction equation
[C:1]1([C:7]([OH:23])([C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:16])[CH2:8][O:9][C:10](=[O:14])[CH2:11][CH2:12]Cl)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[C:10]([O:9][CH2:8][C:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)([OH:23])[C:15]([C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)=[O:16])(=[O:14])[CH:11]=[CH2:12]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 59609081HCID 59609081, compound

Product 1

HCID 59609085HCID 59609085, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

7.8 g (23.4 mmol) (2,3-diphenyl-2-hydroxy-3-oxopropyl)-3-chloro-propionate was dissolved in 75 ml acetone. 4.9 g (35.1 mmol) K2CO3 and 50 mg BHT were added and the mixture was refluxed for 5 hours. The inorganic salts were removed by filtration and the solvent was evaporated under reduced pressure. The residue was treated with 50 ml n.-hexane, 2,3-diphenyl-2-hydroxy-3-oxopropyl acrylate was isolated by filtration and dried. 6.3 g of 2,3-diphenyl-2-hydroxy-3-oxopropyl acrylate (91%) was isolated. Based on 1H-NMR-analysis the conversion proved to be 98%.

Workup

  1. temperaturethe mixture was refluxed for 5 hours
  2. customThe inorganic salts were removed by filtration
  3. customthe solvent was evaporated under reduced pressure
  4. additionThe residue was treated with 50 ml n

Sources & evidence

ORD record
ord-183d4b08e53447e69b2148db9e388fa5
Source dataset
uspto-grants-2014_07
Patent number
US08791289B2

Reaction notes

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