反应详情

温度

40 °C

To a solution of 5-(4-fluoro-benzyl)-3-methoxy-2-(2,4,6-trimethyl-phenyl)-cyclopent-2-enone (136 mg, 0.40 mmol) in acetone (2 ml) is added a 2N solution of hydrochloric acid (2 ml) and the resulting solution is heated to 40° C. by microwave irradiation for 30 minutes. The reaction mixture is diluted with 2N hydrochloric acid (25 ml), and extracted with ethyl acetate (2×25 ml). The combined organics are washed with brine (25 ml), dried over magnesium sulphate, filtered and concentrated in vacuo to give 4-(4-fluoro-benzyl)-2-(2,4,6-trimethyl-phenyl)-cyclopentane-1,3-dione (124 mg).

1. extractionextracted with ethyl acetate (2×25 ml)
2. washThe combined organics are washed with brine (25 ml)
3. dry with materialdried over magnesium sulphate
4. filtrationfiltered
5. concentrationconcentrated in vacuo