ethyl 3-(3,5-dimethyl-1H-pyrazol-4-yl)propanoate → 3-[3,5-Dimethyl-1-(4-nitro-benzyl)-1H-pyrazol-4-yl]-propionic acid ethyl ester

HRID 1631915Notes

Reaction equation

HRID 1631915 reaction equation
CO[C:3](=O)[CH2:4][C:5]1[C:6]([CH3:21])=[N:7][N:8]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][CH:13]=2)[C:9]=1[CH3:10].[CH2:23]([O:25][C:26](=[O:36])CCC1C(C)=NNC=1C)[CH3:24]>>[CH2:23]([O:25][C:26](=[O:36])[CH2:3][CH2:4][C:5]1[C:6]([CH3:21])=[N:7][N:8]([CH2:11][C:12]2[CH:13]=[CH:14][C:15]([N+:18]([O-:20])=[O:19])=[CH:16][CH:17]=2)[C:9]=1[CH3:10])[CH3:24]

Participants

3

Reactant 2

HCID 3410253ethyl 3-(3,5-dimethyl-1H-pyrazol-4-yl)propanoateHCID 66707610[3,5-Dimethyl-1-(4-nitro-benzyl)-1H-pyrazol-4-yl]-acetic acid methyl ester

Product 1

HCID 667073393-[3,5-Dimethyl-1-(4-nitro-benzyl)-1H-pyrazol-4-yl]-propionic acid ethyl ester

Procedure

Intermediate 8.1.1 can be prepared according to the method described for intermediate 1.1.2, employing in the alkylation reaction 3-(3,5-dimethyl-1H-pyrazol-4-yl)-propionic acid ethyl ester (Akos, MFCD03834497) instead of (3,5-dimethyl-1H-pyrazol-4-yl)-acetic acid methyl ester.

Sources & evidence

ORD record
ord-772c55c142eb4f0b845c8587def888ab
Source dataset
uspto-grants-2014_07
Patent number
US08791272B2

Reaction notes

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