反应详情

温度

50 °C

To a solution of (3,5-dimethyl-1H-pyrazol-4-yl)-acetic acid methyl ester (6 g, 36 mmol) and 4-bromobenzyl bromide (8.9 g, 36 mmol) in 80 ml acetonitrile was added K2CO3 (4.9 g, 36 mmol). The mixture was stirred for 12 h at room temperature, 12 h at 50° C., and after addition of an additional 1 g of K2CO3 the mixture was stirred for another 12 h at room temperature. The mixture was concentrated by under reduced pressure, poured into water and extracted twice with ethyl acetate, dried with MgSO4 and evaporated under reduced pressure.

1. stirringwas stirred for another 12 h at room temperature
2. concentrationThe mixture was concentrated by under reduced pressure
3. additionpoured into water
4. extractionextracted twice with ethyl acetate
5. dry with materialdried with MgSO4
6. customevaporated under reduced pressure