反应详情

A solution of 4-(1-bromo-ethyl)-benzoic acid (2.70 g, 11.8 mmol) in diethyl ether (20 mL) and methanol (5 mL) was cooled to 0° C. and treated with trimethylsilyldiazomethane (2 M in diethylether, 11.8 mL). After 1 h at 0° C. the solvents were removed under reduced pressure, the residue was re-dissolved in ethyl acetate (20 mL) and washed with aqueous NaHCO3 solution. The organic layer was collected, dried over MgSO4 and evaporated under reduced pressure.

1. customAfter 1 h at 0° C. the solvents were removed under reduced pressure
2. dissolutionthe residue was re-dissolved in ethyl acetate (20 mL)
3. washwashed with aqueous NaHCO3 solution
4. customThe organic layer was collected
5. dry with materialdried over MgSO4
6. customevaporated under reduced pressure