Hydrochloric Acid → {3,5-Dimethyl-1-[4-(4-trifluoromethyl-phenylsulfanylmethyl)-benzyl]-1H-pyrazol-4-yl}-acetic acid

https://huagongshe.com/reaction/1631929

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	Water	HCID 962	—
Reactant	Sodium Hydroxide	HCID 14798	—
Reactant	{3,5-Dimethyl-1-[4-(4-trifluoromethyl-phenylsulfanylmethyl)-benzyl]-1H-pyrazol-4-yl}-acetic acid methyl ester	HCID 66707258	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	{3,5-Dimethyl-1-[4-(4-trifluoromethyl-phenylsulfanylmethyl)-benzyl]-1H-pyrazol-4-yl}-acetic acid	HCID 58071651	—

Reaction Conditions

Temperature	60 °C

Reaction Steps

{3,5-Dimethyl-1-[4-(4-trifluoromethyl-phenylsulfanylmethyl)-benzyl]-1H-pyrazol-4-yl}-acetic acid methyl ester (intermediate 16.1.3, 80 mg, 0.18 mmol) was dissolved in 2 ml dioxane and aqueous NaOH solution (0.36 ml, 1 M) was added. After stirring for 2.5 h at 60° C. and dilution with water, aqueous HCl solution (0.37 ml, 1 M) was added. The product was isolated by filtration, washed with water and dried under reduced pressure.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08791272B2
Source dataset	uspto-grants-2014_07
ORD ID	ord-af327ff5b00c46118e167f5993b50919
Source note	uspto-grants-2014_07