Hydrochloric Acid → {3,5-Dimethyl-1-[4-(4-trifluoromethyl-benzenesulfinylmethyl)-benzyl]-1H-pyrazol-4-yl}-acetic acid

https://huagongshe.com/reaction/1631931

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	Water	HCID 962	—
Reactant	Sodium Hydroxide	HCID 14798	—
Reactant	{3,5-Dimethyl-1-[4-(4-trifluoromethyl-benzenesulfinylmethyl)-benzyl]-1H-pyrazol-4-yl}-acetic acid methyl ester	HCID 66707530	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	{3,5-Dimethyl-1-[4-(4-trifluoromethyl-benzenesulfinylmethyl)-benzyl]-1H-pyrazol-4-yl}-acetic acid	HCID 58071821	—

Reaction Conditions

Temperature	60 °C

Reaction Steps

{3,5-Dimethyl-1-[4-(4-trifluoromethyl-benzenesulfinylmethyl)-benzyl]-1H-pyrazol-4-yl}-acetic acid methyl ester (intermediate 16.2.1, 60 mg, 0.13 mmol) was dissolved in 2 ml dioxane and 1 ml water and aqueous NaOH solution (0.26 ml, 1 M) was added. After stirring for 1 h at 60° C. and dilution with water, aqueous HCl solution (0.39 ml, 1 M) was added. The mixture was extracted twice with ethyl acetate, the organic layer was dried over MgSO4 and evaporated under reduced pressure.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08791272B2
Source dataset	uspto-grants-2014_07
ORD ID	ord-37539ee22ee7499fb7b02e7551426ab0
Source note	uspto-grants-2014_07