HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → [1-(4-Bromobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl]-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Bromobenzyl bromide | HCID 68527 | — |
| Reactant | methyl 2-(3,5-dimethyl-1H-pyrazol-4-yl)acetate | HCID 7131483 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | [1-(4-Bromobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl]-acetic acid methyl ester | HCID 63276242 | 71.6% |
Reaction Steps
To a solution of (3,5-dimethyl-1H-pyrazol-4-yl)-acetic acid methyl ester (30.7 g) (preparation according to WO2007/141267) in CH3CN (500 ml) was added K2CO3 (43.5 g) and 4-bromobenzylbromide (38.6 g) and the reaction heated to reflux. After 15 h, the reaction was cooled and filtered, the filtrate was then concentrated. The residue was recrystallized from cyclohexane to afford 37.3 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08791272B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-055f0592250c4754ab9e829285dd72b4 |
| Source note | uspto-grants-2014_07 |