反应详情

To a solution of (3,5-dimethyl-1H-pyrazol-4-yl)-acetic acid methyl ester (30.7 g) (preparation according to WO2007/141267) in CH3CN (500 ml) was added K2CO3 (43.5 g) and 4-bromobenzylbromide (38.6 g) and the reaction heated to reflux. After 15 h, the reaction was cooled and filtered, the filtrate was then concentrated. The residue was recrystallized from cyclohexane to afford 37.3 g of the title compound.

1. temperaturethe reaction heated to reflux
2. temperaturethe reaction was cooled
3. filtrationfiltered
4. concentrationthe filtrate was then concentrated
5. customThe residue was recrystallized from cyclohexane