反应详情

A mixture of 11.0 g (39.5 mmol) of diethyl 2-oxobenzimidazole-1,3-dicarboxylate (III), 5.30 g (39.5 mmol) of 2-hydroxybenzimidazole and 6.55 g (47.4 mmol) of potassium carbonate in acetonitrile (200 ml) was heated under reflux with vigorous stirring for 2 h. Most of the solvent was then removed in vacuo, and the residue was mixed with 150 ml of 1N hydrochloric acid. The solid residue was filtered, washed with water, dried in vacuo and recrystallized from toluene.

1. temperaturewas heated
2. temperatureunder reflux
3. customMost of the solvent was then removed in vacuo
4. additionthe residue was mixed with 150 ml of 1N hydrochloric acid
5. filtrationThe solid residue was filtered
6. washwashed with water
7. customdried in vacuo
8. customrecrystallized from toluene