反应详情

温度

45 °C

To the 2-bromo-6-methyl-pyridin-3-ol (I-2) 6.0 g, 31.91 mmol) and K2CO3 (8.82 g, 63.82 mmol) in acetone (100 mL) was added MeI (6.79 g, 479.87 mmol). The reaction was stirred at 45° C. under N2 for 20 h. The reaction was cooled to room temperature, filtered and concentrated. The residue was purified by silica gel column chromatography using 1:1 dichloromethane-hexanes as eluent to afford 2.34 g (36%) of 2-bromo-3-methoxy-6-methyl-pyridine (I-3, X═Br, Y═R1═CH3) as off-white solid.

1. temperatureThe reaction was cooled to room temperature
2. filtrationfiltered
3. concentrationconcentrated
4. customThe residue was purified by silica gel column chromatography