Hydrochloric Acid → HCID 68788318, compound

HRID 1632022Notes

Reaction equation

HRID 1632022 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][CH:11]=[C:10]([C:16]([C:18]3[CH:23]=[CH:22][C:21]([NH:24]C(=O)C)=[CH:20][CH:19]=3)=[O:17])[C:9]=2[F:28])[CH:5]=[CH:6][CH:7]=1.Cl>C(O)C>[ClH:1].[NH2:24][C:21]1[CH:22]=[CH:23][C:18]([C:16]([C:10]2[C:9]([F:28])=[C:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)[C:13]([O:14][CH3:15])=[CH:12][CH:11]=2)=[O:17])=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58019879HCID 58019879, compound

Product 1

HCID 68788318HCID 68788318, compoundYield 48%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a stirred suspension of N-[4-(3′-chloro-2-fluoro-6-methoxy-biphenyl-3-carbonyl)-phenyl]-acetamide synthesized above (1.75 g, 4.44 mmol) in ethanol (40 mL) was added con. HCl (40 mL). The reaction was refluxed for 2 h, cooled to room temperature, filtered, washed with water than hexanes to afford 0.82 g (48%) of (4-amino-phenyl)-(3′-chloro-2-fluoro-6-methoxy-biphenyl-3-yl)-methanone hydrochloride as light yellow solid.

Workup

  1. additionwas added con
  2. temperatureThe reaction was refluxed for 2 h
  3. filtrationfiltered
  4. washwashed with water than hexanes

Sources & evidence

ORD record
ord-c07a1a3dfd3f43f4a7dfb83899c0b42e
Source dataset
uspto-grants-2014_07
Patent number
US08791267B2

Reaction notes

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