反应详情

温度

45 °C

To 2-iodo-6-methyl-pyridin-3-ol (1.0 g, 4.25 mmol) and K2CO3 (1.18 g, 8.51 mmol) in acetone (20 mL) was added MeI (0.91 g, 6.38 mmol). The reaction was stirred at 45° C. under N2 for 20 h. The reaction was cooled to room temperature and concentrated. The residue was purified by silica gel column chromatography using dichloromethane to afford 1.04 g (98%) of I-95 as light yellow solid.

1. temperatureThe reaction was cooled to room temperature
2. concentrationconcentrated
3. customThe residue was purified by silica gel column chromatography
4. customto afford 1.04 g (98%) of I-95 as light yellow solid