Hydrogen Bromide → 1-(1-Methyl-3-bromopropyl)piperidine hydrobromide

HRID 1632302Notes

Reaction equation

HRID 1632302 reaction equation
[CH3:1][CH:2]([N:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)[CH2:3][CH2:4]OC1C=CC=CC=1.[BrH:18]>C(Cl)(Cl)Cl>[BrH:18].[CH3:1][CH:2]([N:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)[CH2:3][CH2:4][Br:18]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 201358121-(1-Methyl-3-phenoxypropyl)piperidine

Product 1

HCID 201359031-(1-Methyl-3-bromopropyl)piperidine hydrobromideYield 75%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

5 g of the 1-(1-methyl-3-phenoxypropyl)piperidine thus obtained was reacted with 30 ml of 40% hydrobromic acid at 150° C. for 7 hours with stirring. The reaction solution was cooled, 20 ml of chloroform was added and then the solution separated into two phases, which phases were then separated from each other. The hydrobromic acid was removed under reduced pressure and the residue was recrystallized from 5 ml of ethyl alcohol to give 4.84 g of 1-(1-methyl-3-bromopropyl)piperidine hydrobromide in a yield of 75%.

Workup

  1. temperatureThe reaction solution was cooled
  2. customthe solution separated into two phases, which phases
  3. customwere then separated from each other
  4. customThe hydrobromic acid was removed under reduced pressure
  5. customthe residue was recrystallized from 5 ml of ethyl alcohol

Sources & evidence

ORD record
ord-30bdefa7087541f09bdb1deebf90dd7e
Source dataset
uspto-grants-1984_10
Patent number
US04474964

Reaction notes

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