Hydrogen Bromide → 1-Methyl-3-bromopropyldimethylamine hydrobromide

HRID 1632307Notes

Reaction equation

HRID 1632307 reaction equation
[CH3:1][CH:2]([N:12]([CH3:14])[CH3:13])[CH2:3][CH2:4]OC1C=CC=CC=1.[BrH:15]>C(Cl)(Cl)Cl>[BrH:15].[CH3:1][CH:2]([N:12]([CH3:14])[CH3:13])[CH2:3][CH2:4][Br:15]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 201358801-Methyl-3-phenoxypropyldimethylamine

Product 1

HCID 201357911-Methyl-3-bromopropyldimethylamine hydrobromideYield 79%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

5 g of the 1-methyl-3-phenoxypropyldimethylamine thus obtained was reacted with 30 ml of 40% hydrobromic acid at 150° C. for 7 hours with stirring. The reaction solution was cooled, 20 ml of chloroform was added and then the solution was separated. The hydrobromic acid was removed under reduced pressure and the residue was recrystallized from 5 ml of ethyl alcohol to give 4.46 g of 1-methyl-3-bromopropyldimethylamine hydrobromide in a yield of 79%.

Workup

  1. temperatureThe reaction solution was cooled
  2. customthe solution was separated
  3. customThe hydrobromic acid was removed under reduced pressure
  4. customthe residue was recrystallized from 5 ml of ethyl alcohol

Sources & evidence

ORD record
ord-beb549ae2b3049aab7d5b6a652a7d191
Source dataset
uspto-grants-1984_10
Patent number
US04474964

Reaction notes

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