Acetic Anhydride → HCID 70511433, compound

HRID 1632317Notes

Reaction equation

HRID 1632317 reaction equation
[ClH:1].[CH:2]([S:5][C:6]1[CH:11]=[CH:10][C:9]([CH:12]([OH:25])[CH:13]([NH:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[CH2:14][CH3:15])=[CH:8][CH:7]=1)([CH3:4])[CH3:3].[C:26](OC(=O)C)(=[O:28])[CH3:27]>C(#N)C>[ClH:1].[C:26]([O:25][CH:12]([C:9]1[CH:10]=[CH:11][C:6]([S:5][CH:2]([CH3:4])[CH3:3])=[CH:7][CH:8]=1)[CH:13]([NH:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[CH2:14][CH3:15])(=[O:28])[CH3:27]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 30428932-(Octylamino)-1-{4-[(propan-2-yl)sulfanyl]phenyl}butan-1-ol--hydrogen chloride (1/1)

Product 1

HCID 70511433HCID 70511433, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To 20 ml of acetonitrile, 5 gr (13 mmol) of 1-(4-isopropylthiophenyl)-2-n-octylamino-1-butanol hydrochloride and 5.3 g (52 mmol) of acetic anhydride are added successively. The mixture is refluxed for 2.5 hours. When cooling, it abandons a white solid. The latter is filtered off and twice recrystallised from acetonitrile.

Workup

  1. temperatureThe mixture is refluxed for 2.5 hours
  2. temperatureWhen cooling
  3. filtrationThe latter is filtered off
  4. customtwice recrystallised from acetonitrile

Sources & evidence

ORD record
ord-a0deff82a0fb43e690c69b93645822ea
Source dataset
uspto-grants-1984_10
Patent number
US04474977

Reaction notes

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