Dimethylformamide → 4-Amino-2-(2-phthalimidoethylthio)pyrimidine

HRID 163236Notes

Reaction equation

HRID 163236 reaction equation
[Br:9][CH2:10][CH2:11][N:12]1[C:13](=[O:22])[c:14]2[c:15]([cH:18][cH:19][cH:20][cH:21]2)[C:16]1=[O:17].[CH3:34][N:35]([CH3:36])[CH:37]=[O:38].[N:23]12[CH2:24][CH2:25][CH2:26][NH:27][CH:28]1[CH:29]=[CH:30][CH2:31][CH2:32][CH2:33]2.[nH:1]1[c:2](=[S:3])[n:4][c:5]([NH2:6])[cH:7][cH:8]1>>[n:1]1[c:2]([S:3][CH2:10][CH2:11][N:12]2[C:13](=[O:22])[c:14]3[c:15]([cH:18][cH:19][cH:20][cH:21]3)[C:16]2=[O:17])[n:4][c:5]([NH2:6])[cH:7][cH:8]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 113251H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-HCID 150726561,2,3,4,6,7,8,10A-octahydropyrimido[1,2-a]azepineHCID 178507915HCID 178507915, compound

Product 1

HCID 212987374-Amino-2-(2-phthalimidoethylthio)pyrimidine

Sources & evidence

ORD record
ord-e19157c05fa54952bf566e3ce4d766ca
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

Loading…