HRID1632389

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID176

Acetic Acid

C2H4O2

HCID260

Hydrogen Bromide

BrH

结构：CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)O

HCID131713839

未命名化合物

PRODUCTS

生成物

结构：CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)O

HCID131713840

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3283

Diethyl Ether

C4H10O

PROCEDURE

实验过程

To 1.10 g of Z-Ile-Leu-Leu-Ala-Gln-OH was added 15 ml of acetic acid solution containing 25% of hydrogen bromide, then the mixture was stirred at a room temperature for 1 hour. After completion of the reaction, dried ether was added to the reaction mixture to obtain H-Ile-Leu-Leu-Ala-Gln-OH.

WORKUP

后处理

additionwas added to the reaction mixture

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2146dda9c8ad4b409195f00bb082765d
来源数据集: uspto-grants-1984_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04474754
来源说明: uspto-grants-1984_10

反应 SMILES

[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:7]([NH:9][C@H:10]([C:15]([NH:17][C@H:18]([C:23]([NH:25][C@H:26]([C:28]([NH:30][C@H:31]([C:37]([OH:39])=[O:38])[CH2:32][CH2:33][C:34](=[O:36])[NH2:35])=[O:29])[CH3:27])=[O:24])[CH2:19][CH:20]([CH3:22])[CH3:21])=[O:16])[CH2:11][CH:12]([CH3:14])[CH3:13])=[O:8])[C@H:3]([CH2:5][CH3:6])[CH3:4].C(O)(=O)C.Br>CCOCC>[NH2:1][C@H:2]([C:7]([NH:9][C@H:10]([C:15]([NH:17][C@H:18]([C:23]([NH:25][C@H:26]([C:28]([NH:30][C@H:31]([C:37]([OH:39])=[O:38])[CH2:32][CH2:33][C:34](=[O:36])[NH2:35])=[O:29])[CH3:27])=[O:24])[CH2:19][CH:20]([CH3:21])[CH3:22])=[O:16])[CH2:11][CH:12]([CH3:14])[CH3:13])=[O:8])[C@H:3]([CH2:5][CH3:6])[CH3:4]