HCID 13150642, compound → HCID 131713868, compound

HRID 1632413Notes

Reaction equation

HRID 1632413 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:7]([NH:9][C@H:10]([C:16]([NH:18][NH:19][C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])=[O:17])[CH2:11][CH2:12][C:13](=[O:15])[NH2:14])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].[H][H]>CO.[Pd]>[NH2:1][C@H:2]([C:7]([NH:9][C@H:10]([C:16]([NH:18][NH:19][C:20]([O:22][C:23]([CH3:25])([CH3:24])[CH3:26])=[O:21])=[O:17])[CH2:11][CH2:12][C:13](=[O:15])[NH2:14])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5]

Participants

5

Reactant 2

HCID 13150642HCID 13150642, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 131713868HCID 131713868, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2.79 Grams of Z-Leu-Gln-NHNHBoc was suspended in 80 ml of methanol, a small amount of palladium black was added to this suspension and the suspension was stirred for 32 hours under the condition of introducing hydrogen gas. After completion of the reaction, the catalyst was removed by suction filtration, the filtrate was subjected to distillation under a reduced pressure, the residue obtained was dried under a reduced pressure in a desiccator to obtain the desired product.

Workup

  1. customAfter completion of the reaction
  2. customthe catalyst was removed by suction filtration
  3. distillationthe filtrate was subjected to distillation under a reduced pressure
  4. customthe residue obtained
  5. customwas dried under a reduced pressure in a desiccator

Sources & evidence

ORD record
ord-83d551683030454d9fa938df546b84c4
Source dataset
uspto-grants-1984_10
Patent number
US04474754

Reaction notes

Loading…