Diethyl Ether → HCID 131713871, compound

HRID 1632416Notes

Reaction equation

HRID 1632416 reaction equation
[NH:1]([C:42]([O:44][CH2:45][C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1)=[O:43])[C@H:2]([C:6]([NH:8][C@H:9]([C:14]([NH:16][C@H:17]([C:22]([NH:24][C@H:25]([C:31]([NH:33][NH:34]C(OC(C)(C)C)=O)=[O:32])[CH2:26][CH2:27][C:28](=[O:30])[NH2:29])=[O:23])[CH2:18][CH:19]([CH3:21])[CH3:20])=[O:15])[CH2:10][C:11](=[O:13])[NH2:12])=[O:7])[C@@H:3]([CH3:5])[OH:4].CCOCC>C(O)(C(F)(F)F)=O>[NH:1]([C:42]([O:44][CH2:45][C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1)=[O:43])[C@H:2]([C:6]([NH:8][C@H:9]([C:14]([NH:16][C@H:17]([C:22]([NH:24][C@H:25]([C:31]([NH:33][NH2:34])=[O:32])[CH2:26][CH2:27][C:28](=[O:30])[NH2:29])=[O:23])[CH2:18][CH:19]([CH3:21])[CH3:20])=[O:15])[CH2:10][C:11](=[O:13])[NH2:12])=[O:7])[C@@H:3]([CH3:5])[OH:4]

Participants

4

Reactant 2

HCID 3283Diethyl EtherHCID 131713872HCID 131713872, compound

Product 1

HCID 131713871HCID 131713871, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

0.91 Gram of Z-Thr-Asn-Leu-Gln-NHNHBoc was dissolved in 8 ml of TFA, and was allowed to stand at a room temperature for 15 minutes. 80 Milliliters of anhydrous ether was added to this solution and the precipitate formed was collected quickly by filtration, washed with anhydrous ether, then was dried under a reduced pressure in a desiccator containing potassium hydroxide-phosphorus pentoxide as the desiccant, to obtain the desired product.

Workup

  1. customthe precipitate formed
  2. filtrationwas collected quickly by filtration
  3. washwashed with anhydrous ether
  4. customwas dried under a reduced pressure in a desiccator
  5. additioncontaining potassium hydroxide-phosphorus pentoxide as the desiccant,

Sources & evidence

ORD record
ord-4ccaaa9bf6bb4a92ab198f720c23f22f
Source dataset
uspto-grants-1984_10
Patent number
US04474754

Reaction notes

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