Hydrazine hydrate (1:1) → HCID 131713876, compound

Participants

Reaction Steps

1.00 Gram of Z-Tyr-Ser-Leu-Ser-OCH3 was dissolved in methanol, then under ice-cooled condition, 0.82 ml of 100%-NH2NH2.H2O was added thereto and the mixture was allowed to stand at a room temperature for 18 hours. Methanol was removed by distillation under a reduced pressure, the residue was solidified by adding ethyl ether, then washed with water to remove an excess of NH2NH2.H2O, reprecipitated from methanol-ether, washed with a hot methanol to obtain 0.81 g of the desired product.

Provenance & Evidence