Hydrazine hydrate (1:1) → HCID 131713876, compound

HRID 1632423Notes

Reaction equation

HRID 1632423 reaction equation
[NH:1]([C:35]([O:37][CH2:38][C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1)=[O:36])[C@H:2]([C:11]([NH:13][C@H:14]([C:17]([NH:19][C@H:20]([C:25]([NH:27][C@H:28]([C:31](OC)=[O:32])[CH2:29][OH:30])=[O:26])[CH2:21][CH:22]([CH3:24])[CH3:23])=[O:18])[CH2:15][OH:16])=[O:12])[CH2:3][C:4]1[CH:9]=[CH:8][C:7](O)=[CH:6][CH:5]=1.[NH2:45][NH2:46].[OH2:47]>CO>[NH:1]([C:35]([O:37][CH2:38][C:39]1[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=1)=[O:36])[C@H:2]([C:11]([NH:13][C@H:14]([C:17]([NH:19][C@H:20]([C:25]([NH:27][C@H:28]([C:29]([NH:45][NH2:46])=[O:30])[CH2:31][OH:32])=[O:26])[CH2:21][CH:22]([CH3:24])[CH3:23])=[O:18])[CH2:15][OH:16])=[O:12])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([OH:47])=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 131713877HCID 131713877, compound

Product 1

HCID 131713876HCID 131713876, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.00 Gram of Z-Tyr-Ser-Leu-Ser-OCH3 was dissolved in methanol, then under ice-cooled condition, 0.82 ml of 100%-NH2NH2.H2O was added thereto and the mixture was allowed to stand at a room temperature for 18 hours. Methanol was removed by distillation under a reduced pressure, the residue was solidified by adding ethyl ether, then washed with water to remove an excess of NH2NH2.H2O, reprecipitated from methanol-ether, washed with a hot methanol to obtain 0.81 g of the desired product.

Workup

  1. additionwas added
  2. customMethanol was removed by distillation under a reduced pressure
  3. additionby adding ethyl ether
  4. washwashed with water
  5. customto remove an excess of NH2NH2.H2O
  6. customreprecipitated from methanol-ether
  7. washwashed with a hot methanol

Sources & evidence

ORD record
ord-b52d88df50254940a371a25f94e08b71
Source dataset
uspto-grants-1984_10
Patent number
US04474754

Reaction notes

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