HCID 178427534, compound → HCID 178427535, compound

HRID 1632433Notes

Reaction equation

HRID 1632433 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:7]([NH:9][C@H:10]([C:16]([NH:18][C@H:19]([C:37]([NH:39][C@H:40]([C:43]([NH:45][C@H:46]([C:49]([OH:51])=[O:50])[CH2:47][OH:48])=[O:44])[CH2:41][OH:42])=[O:38])[CH2:20][CH2:21][CH2:22][NH:23][C:24](=[NH:36])[NH:25][S:26]([C:29]1[CH:35]=[CH:34][C:32]([CH3:33])=[CH:31][CH:30]=1)(=[O:28])=[O:27])=[O:17])[CH2:11][CH2:12][C:13](=[O:15])[NH2:14])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5]>FC(F)(F)C(O)=O>[NH2:1][C@H:2]([C:7]([NH:9][C@H:10]([C:16]([NH:18][C@H:19]([C:37]([NH:39][C@H:40]([C:43]([NH:45][C@H:46]([C:49]([OH:51])=[O:50])[CH2:47][OH:48])=[O:44])[CH2:41][OH:42])=[O:38])[CH2:20][CH2:21][CH2:22][NH:23][C:24](=[NH:36])[NH:25][S:26]([C:29]1[CH:30]=[CH:31][C:32]([CH3:33])=[CH:34][CH:35]=1)(=[O:28])=[O:27])=[O:17])[CH2:11][CH2:12][C:13](=[O:15])[NH2:14])=[O:8])[CH2:3][CH:4]([CH3:5])[CH3:6]

Participants

3

Reactant 1

HCID 178427534HCID 178427534, compound

Product 1

HCID 178427535HCID 178427535, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

1.50 Grams of Boc-Leu-Gln-Arg(Tos)-Ser-Ser-OH was treated with 10 ml of trifluoroacetic acid at a room temperature to remove the tert-butoxycarbonyl group therefrom, dried ether was added to the reaction mixture to crystallize the desired product to obtain H-Leu-Gln-Arg(Tos)-Ser-Ser-OH.

Workup

  1. customto remove the tert-butoxycarbonyl group
  2. additiondried ether was added to the reaction mixture
  3. customto crystallize the desired product

Sources & evidence

ORD record
ord-6709382888a4401096807e4b8704d173
Source dataset
uspto-grants-1984_10
Patent number
US04474754

Reaction notes

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