Potassium Hydroxide → HCID 20442915, compound

HRID 1632473Notes

Reaction equation

HRID 1632473 reaction equation
C/C(/C=C/C=C(\C)/C=C/C1C(C)=CC(OC(F)(F)F)=C(C)C=1C)=C\C(O)=O.[CH3:28]/[C:29](/[CH:36]=[CH:37]/[CH:38]=[C:39](\[CH3:56])/[CH:40]=[CH:41]/[C:42]1[C:47]([Cl:48])=[CH:46][C:45]([O:49][C:50]([F:53])([F:52])[F:51])=[C:44]([CH3:54])[C:43]=1[Cl:55])=[CH:30]\[C:31]([O:33]CC)=[O:32].[OH-].[K+]>O1CCOCC1>[CH3:28]/[C:29](/[CH:36]=[CH:37]/[CH:38]=[C:39](\[CH3:56])/[CH:40]=[CH:41]/[C:42]1[C:47]([Cl:48])=[CH:46][C:45]([O:49][C:50]([F:52])([F:51])[F:53])=[C:44]([CH3:54])[C:43]=1[Cl:55])=[CH:30]\[C:31]([OH:33])=[O:32]

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 13366430HCID 13366430, compoundHCID 13366432HCID 13366432, compound

Product 1

HCID 20442915HCID 20442915, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In a manner similar to that described in Example 5 for preparing (2E,4E,6E,8E)-3,7-dimethyl-9-[2,3,6-trimethyl-4-(trifluoromethoxy)phenyl]-nonatetraenoic acid, 0.04 mol of ethyl (2E,4E,6E,8E)-3,7-dimethyl-9-[2,6-dichloro-3-methyl-4-(trifluoromethoxy)phenyl]-nonatetraenoate in dioxane solution could be treated with 2N methanolic KOH at reflux for 4 hours. Acidification and extractive workup would produce (2E,4E,6E,8E)- 3,7-dimethyl-9-[2,6-dichloro-3-methyl-4-(trifluoromethyoxy)phenyl]-nonatetraenoic acid.

Workup

  1. temperatureat reflux for 4 hours

Sources & evidence

ORD record
ord-73514932d4e347c08730c20dde2f3c2d
Source dataset
uspto-grants-1984_10
Patent number
US04476056

Reaction notes

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