Potassium Hydroxide → HCID 20442915, compound

Participants

Reaction Steps

In a manner similar to that described in Example 5 for preparing (2E,4E,6E,8E)-3,7-dimethyl-9-[2,3,6-trimethyl-4-(trifluoromethoxy)phenyl]-nonatetraenoic acid, 0.04 mol of ethyl (2E,4E,6E,8E)-3,7-dimethyl-9-[2,6-dichloro-3-methyl-4-(trifluoromethoxy)phenyl]-nonatetraenoate in dioxane solution could be treated with 2N methanolic KOH at reflux for 4 hours. Acidification and extractive workup would produce (2E,4E,6E,8E)- 3,7-dimethyl-9-[2,6-dichloro-3-methyl-4-(trifluoromethyoxy)phenyl]-nonatetraenoic acid.

Provenance & Evidence