Triethylamine → HCID 13373840, compound

HRID 1632488Notes

Reaction equation

HRID 1632488 reaction equation
[NH:1]([CH2:3][CH2:4][CH2:5]O)[NH2:2].C(N(CC)CC)C.Cl[C:15]1[O:16][C:17]2[CH:23]=[CH:22][CH:21]=[CH:20][C:18]=2[N:19]=1.[O:24]1CCOC[CH2:25]1>>[O:16]1[C:17]2[CH:23]=[CH:22][CH:21]=[CH:20][C:18]=2[N:19]=[C:15]1[N:1]([CH2:3][CH2:4][CH2:5][CH2:25][OH:24])[NH2:2]

Participants

5

Reactant 4

HCID 8471TriethylamineHCID 119862-ChlorobenzoxazoleHCID 312751,4-Dioxane2×HCID 128868233-Hydrazinylpropan-1-ol

Product 1

HCID 13373840HCID 13373840, compound

Procedure

A solution of 3-hydrazino-1-propanol (18.0 g.) and triethylamine (20.2 g.) in dioxane (300 ml.) was treated dropwise with a solution of 2-chlorobenzoxazole (30.8 g.) in dioxane (40 ml.) at 10° C. The reaction was then stirred at room temperature overnight. The precipitate was filtered and the filtrate concentrated in vacuo. The residue was crystallized from boiling benzene to give 4-[1-(2-benzoxazolyl)hydrazino]butanol, m.p. 87°-90° C.

Workup

  1. filtrationThe precipitate was filtered
  2. concentrationthe filtrate concentrated in vacuo
  3. customThe residue was crystallized

Sources & evidence

ORD record
ord-006b7cfb76344a099a895b3c6c6a83e3
Source dataset
uspto-grants-1984_10
Patent number
US04476137

Reaction notes

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