Sodium Hydroxide → HCID 23706907, compound

HRID 1632505Notes

Reaction equation

HRID 1632505 reaction equation
C([O:3][C:4]([C:6]1[CH:15]=[C:14]([O:16][CH2:17][CH3:18])[C:13]2[C:8](=[CH:9][C:10]([CH3:24])=[C:11]([C:19](=[O:23])[CH2:20][CH2:21][CH3:22])[CH:12]=2)[N:7]=1)=[O:5])C.[OH-].[Na+:26]>C(O)C>[CH2:17]([O:16][C:14]1[C:13]2[C:8](=[CH:9][C:10]([CH3:24])=[C:11]([C:19](=[O:23])[CH2:20][CH2:21][CH3:22])[CH:12]=2)[N:7]=[C:6]([C:4]([O-:5])=[O:3])[CH:15]=1)[CH3:18].[Na+:26]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 54482604HCID 54482604, compound

Product 1

HCID 23706907HCID 23706907, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

6 g of 4-ethoxy-6-butyryl-7-methylquinoline-2-carboxylic acid ethyl ester are dissolved in 150 ml of ethanol, 9 ml of 2N sodium hydroxide solution are added and the mixture is hydrolysed for 15 minutes at room temperature. The precipitated crystals are filtered with suction and recrystallised from water. Sodium 4-ethoxy-6-butyryl-7-methylquinoline-2-carboxylate having a melting point of above 250° C. is obtained. By dissolving in water and acidifying, 4-ethoxy-6-butyryl-7-methylquinoline-2-carboxylic acid is obtained.

Workup

  1. filtrationThe precipitated crystals are filtered with suction
  2. customrecrystallised from water

Sources & evidence

ORD record
ord-41563a3aef104654bc655e0a791d49fd
Source dataset
uspto-grants-1984_10
Patent number
US04476132

Reaction notes

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