Perchloric Acid → HCID 54729706, compound

HRID 1632513Notes

Reaction equation

HRID 1632513 reaction equation
C([O:5][C:6]([C:8]1[C:9](=[O:27])[N:10]([CH2:25][CH3:26])[C:11]2[C:16]([C:17]=1[OH:18])=[CH:15][C:14]([C:19](=[O:23])[CH2:20][CH2:21][CH3:22])=[C:13]([CH3:24])[CH:12]=2)=[O:7])(C)(C)C.Cl(O)(=O)(=O)=O>C(OCC)C>[CH2:25]([N:10]1[C:11]2[C:16](=[CH:15][C:14]([C:19](=[O:23])[CH2:20][CH2:21][CH3:22])=[C:13]([CH3:24])[CH:12]=2)[C:17]([OH:18])=[C:8]([C:6]([OH:7])=[O:5])[C:9]1=[O:27])[CH3:26]

Participants

4

Reactant 2

HCID 24247Perchloric AcidHCID 54737553HCID 54737553, compound

Product 1

HCID 54729706HCID 54729706, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

7.13 g of 1-ethyl-6-butyryl-4-hydroxy-7-methylcarbostyril-3-carboxylic acid tert-butyl ester are suspended in 100 ml of diethyl ether and, while stirring, 2.0 ml of 70% strength perchloric acid are carefully added. The reaction mixture is stirred for 10 minutes at 30°, cooled by means of an ice bath and suction-filtered and the residue is washed twice with a little diethyl ether and subsequently with hexane, then allowed to dry at room temperature. In this manner 1-ethyl-6-butyryl-4-hydroxy-7-methylcarbostyril-3-carboxylic acid having a melting point of 157°-158° is obtained.

Workup

  1. stirringThe reaction mixture is stirred for 10 minutes at 30°
  2. temperaturecooled by means of an ice bath
  3. filtrationsuction-filtered
  4. washthe residue is washed twice with a little diethyl ether and subsequently with hexane
  5. customto dry at room temperature

Sources & evidence

ORD record
ord-2a8a96e6fded4bfbabdfeb8cf42a4710
Source dataset
uspto-grants-1984_10
Patent number
US04476132

Reaction notes

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