Ethanol → HCID 20442989, compound

HRID 1632533Notes

Reaction equation

HRID 1632533 reaction equation
[CH3:1][N:2]1[C:6]([NH:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][N:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)[CH:13]=2)=[N:5][C:4]([CH2:25][CH2:26][CH2:27][C:28]([O-:30])=[O:29])=[N:3]1.[K+].S(=O)(=O)(O)O.[CH2:37](O)[CH3:38]>>[CH3:1][N:2]1[C:6]([NH:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][N:19]3[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]3)[CH:13]=2)=[N:5][C:4]([CH2:25][CH2:26][CH2:27][C:28]([O:30][CH2:37][CH3:38])=[O:29])=[N:3]1

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 23706905HCID 23706905, compound

Product 1

HCID 20442989HCID 20442989, compound

Procedure

Potassium 1-methyl-5[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]amino]-1H-1,2,4-triazole-3-butanoate (2.0 g) and concentrated sulphuric acid (1 ml) in anhydrous ethanol (200 ml) was heated under reflux for 16 h. The suspension was filtered, the filtrate evaporated, and saturated aqueous sodium bicarbonate (50 ml) added. The mixture was extracted with ethyl acetate, the extract washed with brine, dried, and evaporated to give the title compound (1.0 g) as an oil.

Workup

  1. temperatureunder reflux for 16 h
  2. filtrationThe suspension was filtered
  3. customthe filtrate evaporated
  4. additionsaturated aqueous sodium bicarbonate (50 ml) added
  5. extractionThe mixture was extracted with ethyl acetate
  6. washthe extract washed with brine
  7. customdried
  8. customevaporated

Sources & evidence

ORD record
ord-5f6f412c789d4849825a533b097dba67
Source dataset
uspto-grants-1984_10
Patent number
US04476126

Reaction notes

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