Ethanol → HCID 20442989, compound

Participants

Reaction Steps

Potassium 1-methyl-5[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]amino]-1H-1,2,4-triazole-3-butanoate (2.0 g) and concentrated sulphuric acid (1 ml) in anhydrous ethanol (200 ml) was heated under reflux for 16 h. The suspension was filtered, the filtrate evaporated, and saturated aqueous sodium bicarbonate (50 ml) added. The mixture was extracted with ethyl acetate, the extract washed with brine, dried, and evaporated to give the title compound (1.0 g) as an oil.

Provenance & Evidence