反应详情

温度

0 °C

To a stirred, cold (0° C.) solution of 60 g (0.34 mole) of 4,6-dichloro-2-ethylpyrimidine in 500 ml of methanol was added 35 g (0.7 mole) of hydrazine hydrate while maintaining the temperature below 10° C. Stirring was continued for 2 hours after completion of the addition, the temperature being maintained at 0° C. The mixture was allowed to warm to about 20° C. and was stirred for 16 hours. The white solid was collected by filtration and the filtrate was partially evaporated to provide a second crop. The combined solids were washed with water and air dried to provide 51 g (77%) of 4-chloro-2-ethyl-6-hydrazinylpyrimidine, m.p. 147°-150° C.

1. temperaturewhile maintaining the temperature below 10° C
2. additionafter completion of the addition
3. temperatureto warm to about 20° C.
4. stirringwas stirred for 16 hours
5. filtrationThe white solid was collected by filtration
6. customthe filtrate was partially evaporated
7. customto provide a second crop
8. washThe combined solids were washed with water and air
9. customdried