反应详情

A mixture of 8.3 g (0.05 mole) of 4-chloro-2-ethyl-6-hydrazinylpyrimidine and 11 g (0.10 mole) of 1-methylpiperazine in 250 ml of water was heated at reflux for 16 hours and was then cooled and extracted with chloroform. The extracts were dried over magnesium sulfate and were then evaporated to provide 8.3 g (70%) of 2-ethyl-6-hydrazinyl-4-(4-methyl-1-piperazinyl)pyrimidine.

1. temperaturewas heated
2. temperatureat reflux for 16 hours
3. temperaturewas then cooled
4. extractionextracted with chloroform
5. dry with materialThe extracts were dried over magnesium sulfate
6. customwere then evaporated